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currentsinbiology:

Mitochondria may have once been energy parasites

"We believe this study has the potential to change the way we think about the event that led to mitochondria," said U.Va. biologist Martin Wu, the study’s lead author. "We are saying that the current theories — all claiming that the relationship between the bacteria and the host cell at the very beginning of the symbiosis was mutually beneficial — are likely wrong.
"Instead, we believe the relationship likely was antagonistic — that the bacteria were parasitic and only later became beneficial to the host cell by switching the direction of the ATP transport."

Zhang Wang, Martin Wu. Phylogenomic Reconstruction Indicates Mitochondrial Ancestor Was an Energy Parasite. PLOS ONE, 2014 DOI: 10.1371/journal.pone.0110685

currentsinbiology:

Mitochondria may have once been energy parasites

"We believe this study has the potential to change the way we think about the event that led to mitochondria," said U.Va. biologist Martin Wu, the study’s lead author. "We are saying that the current theories — all claiming that the relationship between the bacteria and the host cell at the very beginning of the symbiosis was mutually beneficial — are likely wrong.

"Instead, we believe the relationship likely was antagonistic — that the bacteria were parasitic and only later became beneficial to the host cell by switching the direction of the ATP transport."

Zhang Wang, Martin Wu. Phylogenomic Reconstruction Indicates Mitochondrial Ancestor Was an Energy Parasite. PLOS ONE, 2014 DOI: 10.1371/journal.pone.0110685

uxcritique:

In OS X Yosemite buttons and text input boxes on the toolbar are rendered similarly. As seen in the Safari screenshot above, borders of buttons and text boxes are identical. If there is an icon inside, it must be a button. If there is text inside it must be a text input box. But wait, in Xcode there is text inside one of those round rectangles, but it is neither a button nor a text input box. Also, Apple’s guidelines state that a toolbar button can contain either text or an image, so the presence of text cannot be used to determine if something is a button or a text input box.
So here’s a more reliable way to tell: Click on the widget. If its background momentarily turns gray it is a button. If a blinking caret appears it is a text input box. If it doesn’t seem to respond to the mouse that’s because it is a label.
This is a significant step backwards in usability. Compare this to OS X Mountain Lion. It is instantly obvious whether a control on the toolbar is a button, a text input box or a status label. There is no need to try to manipulate a control just to see what kind of control it is.

uxcritique:

In OS X Yosemite buttons and text input boxes on the toolbar are rendered similarly. As seen in the Safari screenshot above, borders of buttons and text boxes are identical. If there is an icon inside, it must be a button. If there is text inside it must be a text input box. But wait, in Xcode there is text inside one of those round rectangles, but it is neither a button nor a text input box. Also, Apple’s guidelines state that a toolbar button can contain either text or an image, so the presence of text cannot be used to determine if something is a button or a text input box.

So here’s a more reliable way to tell: Click on the widget. If its background momentarily turns gray it is a button. If a blinking caret appears it is a text input box. If it doesn’t seem to respond to the mouse that’s because it is a label.

This is a significant step backwards in usability. Compare this to OS X Mountain Lion. It is instantly obvious whether a control on the toolbar is a button, a text input box or a status label. There is no need to try to manipulate a control just to see what kind of control it is.

fuckyeahbehindthescenes:

In order to acquaint himself with his three lead actors, director Alfonso Cuarón had each of them write an essay about their characters, from a first-person point of view. Emma Watson wrote a 10-page essay. Daniel Radcliffe wrote a one-page summary, and Rupert Grint never even turned his in. (x)
Harry Potter and the Prisoner of Azkaban (2004)

fuckyeahbehindthescenes:

In order to acquaint himself with his three lead actors, director Alfonso Cuarón had each of them write an essay about their characters, from a first-person point of view. Emma Watson wrote a 10-page essay. Daniel Radcliffe wrote a one-page summary, and Rupert Grint never even turned his in. (x)

Harry Potter and the Prisoner of Azkaban (2004)

fuckyeahbehindthescenes:

Heath Ledger did not need to go to the one month cowboy camp that had been organized as he had grown up on farms in Western Australia. Jake Gyllenhaal was required to attend, however, as he needed “roughing up”. (x)
Brokeback Mountain (2005)

fuckyeahbehindthescenes:

Heath Ledger did not need to go to the one month cowboy camp that had been organized as he had grown up on farms in Western Australia. Jake Gyllenhaal was required to attend, however, as he needed “roughing up”. (x)

Brokeback Mountain (2005)

humansofnewyork:

“I’ve written so many stories and novellas that nobody will look at, plays that I can’t get produced, screenplays that will never be made. Everything is so branded these days in the art world, it’s so hard for an outsider to get work.”
“In what way would you consider yourself an ‘outsider?’”
“I’m interested in failure, so those are the themes that I like to explore. But we live in a society that celebrates triumphalism. A society wants art that reaffirms itself. We want to read about characters that win.” “What was your lowest moment as an artist?”“I worked on a screenplay for two years, and it had just been turned down by the fifth theater in a month, and I remember walking down 5th avenue in the middle of winter, tossing the pages one by one into the slush, vowing never to do it again. It was just a few blocks from here, actually.”

humansofnewyork:

“I’ve written so many stories and novellas that nobody will look at, plays that I can’t get produced, screenplays that will never be made. Everything is so branded these days in the art world, it’s so hard for an outsider to get work.”

“In what way would you consider yourself an ‘outsider?’”

“I’m interested in failure, so those are the themes that I like to explore. But we live in a society that celebrates triumphalism. A society wants art that reaffirms itself. We want to read about characters that win.” 
“What was your lowest moment as an artist?”
“I worked on a screenplay for two years, and it had just been turned down by the fifth theater in a month, and I remember walking down 5th avenue in the middle of winter, tossing the pages one by one into the slush, vowing never to do it again. It was just a few blocks from here, actually.”

hannahchristenson:

Ah HA! Was anyone expecting a winged bear?! The lady there has a name and a story, hers is one of several personal project stories I have in the works. I hope to be able to show more from her story and others soon. This was a fun drawing, I’m thinking about painting it one of these days. :)

hannahchristenson:

Ah HA! Was anyone expecting a winged bear?! The lady there has a name and a story, hers is one of several personal project stories I have in the works. I hope to be able to show more from her story and others soon. This was a fun drawing, I’m thinking about painting it one of these days. :)

itsliketheyknowus:

"Mom, I’m getting kinda hungry… Hey, um, Mom, you’ve been stirring that empty pot for 2 hours. Is the stove even on?…Mom? Mom? Mom…what happened to Dad?"

itsliketheyknowus:

"Mom, I’m getting kinda hungry… Hey, um, Mom, you’ve been stirring that empty pot for 2 hours. Is the stove even on?…Mom? Mom? Mom…what happened to Dad?"

humansofnewyork:

"I was tired of working retail, so I lied on my resume and said that I had bookkeeper experience. I learned as much as I could from Google before the job interview, and printed out balance sheets to practice on. After I got the job, I read as much as I could every morning on the train. It was nerve wracking at first, but I presented the numbers at the end of the month, and everything checked out. May not have been the best way to get a job, but hey— I’ve got a son to look out for."

humansofnewyork:

"I was tired of working retail, so I lied on my resume and said that I had bookkeeper experience. I learned as much as I could from Google before the job interview, and printed out balance sheets to practice on. After I got the job, I read as much as I could every morning on the train. It was nerve wracking at first, but I presented the numbers at the end of the month, and everything checked out. May not have been the best way to get a job, but hey— I’ve got a son to look out for."